Amino acids, often referred to as the building blocks of proteins, are compounds that play many critical roles in your body.
They're needed for vital processes like the building of proteins and synthesis of hormones and neurotransmitters.
Some may also be taken in supplement form for a natural way to boost athletic performance or improve mood.
They’re categorized as essential, conditionally essential or nonessential depending on several factors.
This article tells you everything you need to know about essential amino acids, including how they function, possible food sources and the benefits of taking a supplement.
What Are Essential Amino Acids?
Your body needs 20 different amino acids to grow and function properly. Though all 20 of these are important for your health, only nine amino acids are classified as essential (
These are histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine.
Unlike nonessential amino acids, essential amino acids can’t be made by your body and must be obtained through your diet.
When you eat protein, it’s broken down into amino acids, which are then used to help your body with various processes such as building muscle and regulating immune function (
Conditionally Essential Amino Acids
There are several nonessential amino acids that are classified as conditionally essential.
These are considered to be essential only under specific circumstances such as illness or stress.
For example, although arginine is considered nonessential, your body can’t meet demands when fighting certain diseases like cancer (
That’s why arginine must be supplemented through diet in order to meet your body’s needs in certain situations.
SUMMARY // The nine essential amino acids can’t be produced by your body and must be obtained through your diet. Conditionally essential amino acids are only essential under special circumstances like illness.
Their Roles in Your Body
The nine essential amino acids perform a number of important and varied jobs in your body:
- Phenylalanine: Phenylalanine is a precursor for the neurotransmitters tyrosine, dopamine, epinephrine and norepinephrine. It plays an integral role in the structure and function of proteins and enzymes and the production of other amino acids (4).
- Valine: Valine is one of three branched-chain amino acids, meaning it has a chain branching off to one side of its molecular structure. Valine helps stimulate muscle growth and regeneration and is involved in energy production (5).
- Threonine: Threonine is a principal part of structural proteins such as collagen and elastin, which are important components of the skin and connective tissue. It also plays a role in fat metabolism and immune function (6).
- Tryptophan: Though often associated with causing drowsiness, tryptophan has many other functions. It’s needed to maintain proper nitrogen balance and is a precursor to serotonin, a neurotransmitter that regulates your appetite, sleep and mood (7).
- Methionine: Methionine plays an important role in metabolism and detoxification. It’s also necessary for tissue growth and the absorption of zinc and selenium, minerals that are vital to your health (8).
- Leucine: Like valine, leucine is a branched-chain amino acid that is critical for protein synthesis and muscle repair. It also helps regulate blood sugar levels, stimulates wound healing and produces growth hormones (9).
- Isoleucine: The last of the three branched-chain amino acids, isoleucine is involved in muscle metabolism and is heavily concentrated in muscle tissue. It’s also important for immune function, hemoglobin production and energy regulation (10).
- Lysine: Lysine plays major roles in protein synthesis, hormone and enzyme production and the absorption of calcium. It’s also important for energy production, immune function and the production of collagen and elastin (11).
- Histidine: Histidine is used to produce histamine, a neurotransmitter that is vital to immune response, digestion, sexual function and sleep-wake cycles. It’s critical for maintaining the myelin sheath, a protective barrier that surrounds your nerve cells (12).
As you can see, essential amino acids are at the core of many vital processes.
Though amino acids are most recognized for their role in muscle development and repair, the body depends on them for so much more.
That’s why essential amino acid deficiencies can negatively impact your entire body including your nervous, reproductive, immune and digestive systems.
SUMMARY // All nine essential amino acids perform varied roles in your body. They’re involved in important processes such as tissue growth, energy production, immune function, and nutrient absorption.
Health Benefits of Supplementing With Essential Amino Acids
While essential amino acids can be found in a wide array of foods, taking concentrated doses in supplemental form has been linked to several health benefits.
May Help Improve Mood and Sleep
Tryptophan is needed for the production of serotonin, a chemical that acts as a neurotransmitter in your body. Serotonin is an essential regulator of mood, sleep and behaviors. While low serotonin levels have been linked to depressed mood and sleep disturbances, several studies have shown that supplementing with tryptophan can reduce symptoms of depression, boost mood and improve sleep (
Can Boost Exercise Performance
The three branched-chain essential amino acids are widely used to alleviate fatigue, improve athletic performance and stimulate muscle recovery after exercise. In a study in 16 resistance-trained athletes, branched-chain amino acid supplements improved performance and muscle recovery and decreased muscle soreness, compared to a placebo (19Trusted Source). A recent review of eight studies found that supplementing with branched-chain amino acids was superior to rest in promoting muscle recovery and reducing soreness after exhaustive exercise (20Trusted Source). Additionally, taking 4 grams of leucine per day for 12 weeks increased strength performance in untrained men, showing that essential amino acids can benefit non-athletes as well (21Trusted Source).
Can Prevent Muscle Loss
Muscle loss is a common side effect of prolonged illnesses and bed rest, especially in older adults. Essential amino acids have been found to prevent muscle breakdown and preserve lean body mass. A 10-day study in 22 older adults on bed rest showed that those who received 15 grams of mixed essential amino acids maintained muscle protein synthesis, while the process decreased by 30% in the placebo group (22Trusted Source). Essential amino acid supplements have also been found to be effective in preserving lean body mass in elderly people and athletes (23Trusted Source,24Trusted Source).
May Promote Weight Loss Some human and animal studies have demonstrated that branched-chain essential amino acids may be effective in stimulating fat loss. For example, an eight-week study in 36 strength-trained men found that supplementing with 14 grams of branched-chain amino acids per day significantly decreased body fat percentage, compared to whey protein or a sports drink (25Trusted Source). A study in rats showed that a diet composed of 4% supplemental leucine reduced body weight and fat (26Trusted Source).
However, other studies investigating the potential link between branched-chain amino acids and weight loss have been inconsistent. More studies are needed to determine if these amino acids can promote weight loss (27Trusted Source, 28Trusted Source).
SUMMARY // Supplementing with certain essential amino acids may help improve mood, boost exercise performance, prevent muscle loss and promote weight loss.
Food Sources and Recommended Intake
Since your body cannot produce essential amino acids, they must be provided through your diet. Fortunately, many foods are rich in essential amino acids, making it easy to meet your daily needs. The US recommended daily allowances per 2.2 pounds (1 kg) of body weight for the nine essential amino acids are (29):
- Histidine: 14 mg
- Isoleucine: 19 mg
- Leucine: 42 mg
- Lysine: 38 mg
- Methionine (+ the non-essential amino acid cysteine): 19 mg
- Phenylalanine (+ the non-essential amino acid tyrosine): 33 mg
- Threonine: 20 mg
- Tryptophan: 5 mg
- Valine: 24 mg
Foods that contain all nine essential amino acids are referred to as complete proteins.
Soy, quinoa and buckwheat are plant-based foods that contain all nine essential amino acids, making them complete protein sources as well (
SUMMARY // Both animal and plant products, such as meat, eggs, quinoa and soy, can contain all nine essential amino acids and are considered complete proteins.
